
Depression. Serotonin. Myths.
Over the years I have noticed something very strange in the antidepressant literature. When antidepressants are compared with one another, their effects are remarkably similar. I first noticed this when Guy Sapirstein and I ran our meta-analysis of the published literature in 1998. When we first saw how weak the actual drug effect was, we thought we might have done something wrong. Perhaps we had made a mistake and included trials that tested different types of antidepressants. Perhaps we had underestimated the true









